○Masashi Kanayama1 Nobuyuki Onai2 Toshiaki Ohteki11 Dept. of Biodefense Res., Med. Res. Lab., Inst. of Integr. Res., Inst. of Sci. Tokyo.2 Dept. of Immunology, Kanazawa Med. Univ.Lymphoid-derived conventional dendritic cells in barrier tissuesBarrier tissue homeostasis is achieved by suppressing unnecessary immune responses and eliminating invading pathogens. Although conventional dendritic cells (cDCs) play critical roles in induction of adaptive immunity, it has not been fully elucidated how barrier tissue cDCs differed from cDCs in other organs. In this study, we originally generated lymphoid-tracing mice and found that most cDC2s in barrier tissues such as the lungs and skin originated from lymphoid progenitors. On the other hand, myeloid-derived cDCs (M-cDCs) were predominant in cDC fractions of other organs. Compared to M-cDCs, the lymphoid-derived cDCs (L-cDCs) showed reduced production of TNF-α in response to LPS. Furthermore, the T cell priming capacity of L-cDCs under a low antigen concentration was weaker than that of M-cDCs. On the other hand, L-cDCs preferentially induced Th2 differentiation under a high antigen concentration. As possible mechanisms for the preferential Th2 induction by L-cDCs, we found that L-cDCs highly expressed CD80/86. These results suggested that the abundance of L-cDCs in barrier tissues may serve to suppress unwanted inflammation against foreign antigens and may relate to the pathogenesis of Th2-mediated inflammation, such as asthma and atopic dermatitis. 40P 010
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